engleski

Impact of PLA2 gene polymorphisms on onset of schizophrenia and illness severity

Background Phospholipases A2 (PLA2) are suspected to be involved in the pathology of schizophrenia ; positive association has been found in Chinese, Korean and Brasilian population. We tested whether risk for schizophrenia in Croatian population was associated with allelic and genotype frequencies of single nucleotide polymorphisms (SNPs) in three genes of PLA2 superfamily: rs1549637 of the PLA2G4C, BanI of the PLA2G4A and rs4375 of the PLA2G6A. We also tested their possible impact on age of onset and symptom severity. Methods Allelic and genotype frequencies were determined in 159 Croatian schizophrenic patients and 187 healthy controls by PCR-RFLP analysis. Association between mean age at first hospital admission and data of PANSS score (positive and negative symptom scale) with SNPs allelic and genotypic variations or their combinations in 81 schizophrenic patients were tested by nonparametric correlations. Results Genotype and allelic frequencies between patients and controls did not show significant difference (χ2 -test). BanI polymorphism significantly impacted the onset of disease indicating lower mean age at admission in homozygous A2A2 males. Increased symptom severity during a psychotic state correlated significantly (in all patients as well in males separately) with the presence of the PLA2G4C-T and absence of the PLA2G4A-A2 allele. The presence of PLA2G6A-C, alone, or synergizing with PLA2G4C-T allele increased symptom severity only in males. PLA2G4A-A2, alone, in combination with PLA2G4C-A or PLA2G6-T tended to decrease symptom severity. Conclusions SNPs: rs1549637, BanI and rs4375, alone and in combination may contribute to variable clinical expression of schizophrenia, possibly by modulating PLA2 expression/activity.

phospholipase A2 gene family; single nucleotide polymorphisms; schizophrenia; PANSS

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