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izvor podataka: crosbi

Cytomegaloviral control of MHC class I function in the mouse (CROSBI ID 88163)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Hengel, Hartmut ; Reusch, Uwe ; Gutermann, Anja ; Ziegler, Heike ; Jonjić, Stipan ; Lucin, Pero ; Koszinowski, Ulrich H Cytomegaloviral control of MHC class I function in the mouse // Immunological reviews, 168 (1999), Apr.; 167-176

Podaci o odgovornosti

Hengel, Hartmut ; Reusch, Uwe ; Gutermann, Anja ; Ziegler, Heike ; Jonjić, Stipan ; Lucin, Pero ; Koszinowski, Ulrich H

engleski

Cytomegaloviral control of MHC class I function in the mouse

Cytomegaloviruses (CMVs) represent prototypic viruses of the beta-subgroup of herpesviruses. Murine cytomegalovirus (MCMV) infects mice as its natural host. Among viruses, CMVs have evolved the most extensive genetic repertoire to subvert MHC class I functions. To date three MCMV proteins have been identified which affect MHC I complexes. They are encoded by members of large virus-specific gene Families located at either flanking region of the 235 kb MCMV genome. The MHC I subversive genes belong to the early class of genes and code for type I transmembrane glycoproteins. The ml52-encoded 37/40 kDa glycoprotein interacts with MHC I transiently and retains class I complexes in the endoplasmic reticulum (ER) Golgi intermediate compartment on its journey to the endolysosome. In contrast, the m06-encoded glycoprotein of 48 kDa complexes tightly with ternary MHC class I molecules in the ER. Due to sorting signals in its cytoplasmic tail, gp48 redirects MHC I to endolysosomal compartments for proteolytic destruction. Likewise, the 34 kDa glycoprotein encoded by m04 binds tightly to MHC class I complexes in the ER but the gp34/MHC I complex reaches the plasma membrane. The CD8(+) T-cell-dependent attenuation of a m152 deletion mutant virus proves for the first time that inhibition of antigen presentation is indeed essential for the biological fitness of CMVs in vivo.

Natural-killer-cells. Inhibits peptide translocation. Endoplasmic-reticulum. Murine cytomegalovirus. Antigen presentation. Heavy-chains. Invariant chain. Infected cells. Lymphocytes-t. Ifn-gamma

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Podaci o izdanju

168 (Apr.)

1999.

167-176

objavljeno

0105-2896

Povezanost rada

Veterinarska medicina

Indeksiranost