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Brain free fatty acid accumulation in hypoxia and epilepsy (CROSBI ID 475338)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Župan, Gordana ; Varljen, Jadranka ; Eraković, Vesna ; Mršić, Jasenka ; Križ, Jasna ; Simonić, Ante ; Milin, Čedomila Brain free fatty acid accumulation in hypoxia and epilepsy // The eight international symposium on pharmaceutical and biomedical analysis. 1997. str. 85-85-x

Podaci o odgovornosti

Župan, Gordana ; Varljen, Jadranka ; Eraković, Vesna ; Mršić, Jasenka ; Križ, Jasna ; Simonić, Ante ; Milin, Čedomila

engleski

Brain free fatty acid accumulation in hypoxia and epilepsy

Numerous pathological conditions, including hypoxia and epilepsy, are accompanied by an increase in intracellular phospholipases A2 and C, degradation of membrane phospholipids and liberation of cerebral firee fatty acids (FFA). The aim of this study was to determine accumulation dynamics of the brain FFA in rats exposed to controlled hypoxia and experimental epilepsy. The animals of the first group were subjected to hypoxia procedure and decapitated immediately, 5, 15 and 60 minutes after loosing the righting reflex. The second group received penicillin (5000 U/5microL) into the left lateral ventricle and were decapitated immediately, 5 or 15 minutes after the appearance of epileptic seizures. The brains were quickly removed and lipids were extracted. FFA were separated using TLC and after methylation quantified by gas chromatography. An increase in total brain FFA content and fiee arachidonic acid was detected in hypoxia-exposed rats with the maximum level at 60 min and 15 min respectively after loosing the righting reflex. Seizures produced an increase in all determined FFA reaching a statistically significant level 5 min after their appearance.

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Podaci o prilogu

85-85-x.

1997.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

The eight international symposium on pharmaceutical and biomedical analysis

Podaci o skupu

The Eight International Symposium on Pharmaceutical and Biomedical Analysis

poster

04.05.1997-07.05.1997

Kissimmee (FL), Sjedinjene Američke Države

Povezanost rada

Temeljne medicinske znanosti