engleski

The anti-inflammatory activity of clarithromycin inhibits TNFa production and prolongs survival following lipopolysaccharide administration in mice

Macrolide antibiotics, well known for their antimicrobial properties, also possess a range of anti-inflammatory and immunomodulatory properties. They were shown to be inhibitory on acute inflammatory processes involved in sepsis. The efficacy of these drugs in sepsis could be attributed to their ability to inhibit production of various inflammatory mediators, including tumour necrosis factor alpha (TNF-α), a central mediator in septic shock.In order to clarify whether efficacy of clarithromycin in sepsis can be attributed solely to its anti-inflammatory and not antimicrobial effects, we have tested the ability of clarithromycin to ameliorate bacterial lipopolysaccharide (LPS)-induced plasma TNF-α production and septic shock in mice. Clarithromycin significantly decreased plasma TNF-α concentration and prolonged survival of experimental animals. Our results clearly demonstrate that clarithromycin can attenuate the inflammatory cascade induced by LPS and unambiguously support distinction between its antimicrobial and anti-inflammatory properties.

clarithromycin; inflammation; TNFa; LPS

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