Lamotrigine: influence on the passive avoidance behavior in electroconvulsive shock-treated rats (CROSBI ID 475424)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Vitezić, Dinko ; Župan, Gordana ; Mršić, Jasenka ; Simonić, Ante
engleski
Lamotrigine: influence on the passive avoidance behavior in electroconvulsive shock-treated rats
Lamotrigine (LTG) is an antiepileptic drug with the actions at the neuronal voltage-gated sodium channel and as a glutamate release inhibitor. The effects of various doses (1, 10 or 30 mg/kg) of LTG on the learning ability in rats exposed to electroconvulsive shock (ECS) were examined. The animals were trained in a passive avoidance procedure. LTG had been injected 30 min before the leaming trial started. The electroconvulsive shock was given immediately after the leaming trial response had been acquired. A passive avoidance retention test was performed 24 hours later. It was found that ECS strongly impaired the retention of the passive avoidance response. LTG did not influence the passive avoidance behavior in the sham ECS group. Retention deficit in the animals exposed to ECS were significantly improved with LTG in the doses of 10 and 30 mg/kg. In conclusion, these findings support the hypothesis that perturbations in ionic homeostasis and excessive glutamate release can contribute to the memory deficits associated with ECS administration. Because of the antiamnestic effect, LTG can be an interesting candidate for clinical trials in patients with cognitive impairment causes by electroconvulsive therapy.
lamotrigine; electroconvulsive shock
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Podaci o prilogu
40-41.
2000.
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objavljeno
Podaci o matičnoj publikaciji
Journal of neural transmission. Supplementum
0303-6995
Podaci o skupu
Congress of the European Society for Clinical Neuropharmacology (5 ; 2000)
poster
17.05.2000-21.05.2000
Opatija, Hrvatska