Influence of nimodipine and amlodipine on the passive avoidance behaviour in rats exposed to electroconvulsive shock (CROSBI ID 475431)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Vitezić, Dinko ; Župan, Gordana ; Mršić, Jasenka ; Matešić, Damir ; Simonić, Ante
engleski
Influence of nimodipine and amlodipine on the passive avoidance behaviour in rats exposed to electroconvulsive shock
The influence of nimodipine and amlodipine on the learning ability in rats exposed to electroconwlsive shock (ECS) was examined. Various doses (0.03, 0.1, 0.3 or 1.0 mg/kg) of the Ca2+ channel blockers tested had been injected 30 min before the passive avoidance procedure started. The ECS was given immediately after the learning trial response had been acquired. A passive avoidance retention test was performed 24 h later. It was found that ECS strongly impaired the retention of the passive avoidance response. Nimodipine and amlodipine did not influence the passive avoidance behaviour in the sham ECS group, but significantly improved the retention deficits in the animals exposed to ECS. These findings support the hypothesis that perturbations in Ca2+ homeostasis can contribute to the memory deficits associated with ECS administration. The antiamnestic effects of the Ca2+ channel blockers tested make them interesting candidates for clinical trials in patients with cognitive impairment caused by electroconvulsive therapy.
electroconvulsive shock; nimodipine; amlodipine; passive avoidance
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Podaci o prilogu
33-33-x.
1997.
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objavljeno
Podaci o matičnoj publikaciji
Periodicum Biologorum (ISSN:0031-5362), Vol 99, Suppl 1
Vitale, Branko
Zagreb: Hrvatsko prirodoslovno društvo
Podaci o skupu
2nd Croatian Congress of Pharmacology with International Participation
poster
09.09.1997-13.09.1997
Rijeka, Hrvatska