400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens (CROSBI ID 165484)
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Podaci o odgovornosti
Fajdetić, Andreja ; Čipčić Paljetak, Hana ; Lazarevski, Gorjana ; Hutinec, Anton ; Alihodžić, Sulejman ; Ðerek, Marko ; Štimac, Vlado ; Andreotti, Danielle ; Šunjić, Vitomir ; Berge, John ; Mutak, Stjepan ; Dumić, Miljenko ; Lociuro, Sergio ; Holmes, David ; Maršić, Nataša ; Eraković Haber, Vesna ; Spaventi, Radan
engleski
400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens
Four macrolides—6-O-methyl-8a-aza-8a- homoerythromycin, clarithromycin, azithromycin and azithromycin 11, 12-cyclic carbonate, have been selected for the construction of a series of new quinolone derivatives. The quinolone moiety is connected to the macrolide scaffold via a diaminoaklyl 400-O-propionyl ester chain of varying length. At the terminus the linker is attached via one of the nitrogen atoms in the linker at C(6) or C(7) of the quinolone. Many of compounds described, particularly clarithromycin derivative 37, and azithromycin derivatives 48 and 55, exhibited excellent antibacterial activity against a wide range of clinically relevant macrolide-resistant organisms, with profiles superior to that of telithromycin, an enhanced spectrum ketolide.
macrolide; quinolone; antibacterial activity; resistance
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Podaci o izdanju
18 (17)
2010.
6559-6568
objavljeno
0968-0896
10.1016/j.bmc.2010.06.049