engleski

Synthesis and crystal structures of novel pentacyclo[5.4.0.02, 6.03, 10.05, 9]undecane hydrazones

It has been known for some time now that the toxicity of hydrazines is a limiting factor in their use in medicine as they can cause severe liver degenerations.[1] As polycyclic cage moieties have been extensively used to modify the potency of biologically active compounds, [2] we plan to investigate a potential biological activity of this type of compounds as we expect less toxic side effects in vivo due to their pronounced lipophilic character. Starting from diketone 1[3], pentacyclo[5.4.0.02, 6.03, 10.05, 9]undecane-8, 11-dione bis(diphenylhydrazone) 3 was synthesized and the obtained mixture of isomers was successfully separated and fully characterized. We also obtained the crystal structures of isomers 3b and 3c, thus confirming our assumptions regarding the configuration and stability of the isomers and thereby enabling the biological studies with the pure isomers of a known structure.

hydrazines; polycyclic cage; toxicity

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