Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against both the adaptive and innate immune response (CROSBI ID 475591)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Krmpotić, Astrid ; Bubić, Ivan ; Hengel, Hartmut ; Koszinowski, Urlich ; Jonjić, Stipan The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against both the adaptive and innate immune response // 25th Intenational Herpesvirus Workshop / Johnson, David ; Nelson, Jay (ur.). Portland (OR), 2000. str. 5.22-x

Podaci o odgovornosti

Krmpotić, Astrid ; Bubić, Ivan ; Hengel, Hartmut ; Koszinowski, Urlich ; Jonjić, Stipan

engleski

The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against both the adaptive and innate immune response

The mouse cytomegalovirus (MCMV) glycoprotein gp40, encoded by the m152 gene retains murine MHC class I complexes in the ERGIC/cis-Golgi compartment (Ziegler et al., Immunity 6:57, 1997). We have shown by studies in mice with specific MCMV deletion mutats, that m152 does affect he adaptive CD8 T cell control in vivo(Krmpotić et al., J. Exp. Med.190:1285, 1999). However, contrary to the expected, the deletion of the m152 function, although associates with increased MHC class I expression, renders the virus more sensitive to NK cells. This NK cell sensitizing effect is mouse stran specific. Since infected cells from responder and nonresponder strains are recognized, specificity is defined at the level of the NK cell receptor. The absence of NK phenotype after infusion of infected ß2m-deficient cells implies that the NK cells that mediated the effect recognize an ß2m-associated structure. In conclusion, we showed for the first time that a herpesvirus protein can downmodulate both the adoptive and the innate immune response.

cytomegalovirus; immunoevasion; m152; NK cell

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

5.22-x.

2000.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

25th Intenational Herpesvirus Workshop

Johnson, David ; Nelson, Jay

Portland (OR):

Podaci o skupu

25th International Herpesvirus Workshop

poster

29.07.2000-04.08.2000

Portland (OR), Sjedinjene Američke Države

Povezanost rada

Temeljne medicinske znanosti