Synthesis and Biological Activity of Quercetin Derivatives of Endogenous Opioid Peptides Leu- and Met-enkephalin (CROSBI ID 567570)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa
Podaci o odgovornosti
Jakas, Andreja ; Bjeliš, Nina ; Piantanida, Ivo ; Kralj, Marijeta
engleski
Synthesis and Biological Activity of Quercetin Derivatives of Endogenous Opioid Peptides Leu- and Met-enkephalin
Quercetin, 3, 3', 4', 5, 7-pentahydroxyflavon is well-known flavonoid distributed ubiquitously as a glycoside in fruits, vegetables and herbs (apples, onions, Ginkgo biloba) and related products, specially in red wine. In plants, flavonoids are involved in energy production and exhibit strong anti-oxidant properties, possibly protecting plants against harmful ultraviolet rays. Quercetin has become a subject of many investigations because of strong anti-cancer, anti-inflammatory, anti-oxidative and other therapeutic activities of significant potency such as cardioprotective, bacteriostatic and nevertheless its systemic toxicity is quite low. In this paper quercetin derivatives of endogenous opioid peptides Leu- and Met-enkephalin (H-Tyr-Gly-Gly-Phe-Leu/Met-OH) were prepared starting from differently protected N-terminal amino group (Boc- or Z- protection). Different protecting groups were used to exchange the position and number of bounded peptide. Modifications were performed in intention to increase biological activity of quercetine as well as enkephalins which also examine antitumor activity. Antitumor evaluation and interactions with ct-DNA of prepared compounds were investigated.
Quercetin ; Biological Activity ; Enkephalin
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Podaci o prilogu
123-123.
2010.
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objavljeno
Podaci o matičnoj publikaciji
Journal of peptide science
Moroder, Luis
Chichester: John Wiley & Sons
1075-2617
Podaci o skupu
31st European Peptide Symposium
poster
05.09.2010-09.09.2010
Kopenhagen, Danska