Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Synthesis and Biological Activity of Quercetin Derivatives of Endogenous Opioid Peptides Leu- and Met-enkephalin (CROSBI ID 567570)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa

Jakas, Andreja ; Bjeliš, Nina ; Piantanida, Ivo ; Kralj, Marijeta Synthesis and Biological Activity of Quercetin Derivatives of Endogenous Opioid Peptides Leu- and Met-enkephalin // Journal of peptide science / Moroder, Luis (ur.). 2010. str. 123-123

Podaci o odgovornosti

Jakas, Andreja ; Bjeliš, Nina ; Piantanida, Ivo ; Kralj, Marijeta

engleski

Synthesis and Biological Activity of Quercetin Derivatives of Endogenous Opioid Peptides Leu- and Met-enkephalin

Quercetin, 3, 3', 4', 5, 7-pentahydroxyflavon is well-known flavonoid distributed ubiquitously as a glycoside in fruits, vegetables and herbs (apples, onions, Ginkgo biloba) and related products, specially in red wine. In plants, flavonoids are involved in energy production and exhibit strong anti-oxidant properties, possibly protecting plants against harmful ultraviolet rays. Quercetin has become a subject of many investigations because of strong anti-cancer, anti-inflammatory, anti-oxidative and other therapeutic activities of significant potency such as cardioprotective, bacteriostatic and nevertheless its systemic toxicity is quite low. In this paper quercetin derivatives of endogenous opioid peptides Leu- and Met-enkephalin (H-Tyr-Gly-Gly-Phe-Leu/Met-OH) were prepared starting from differently protected N-terminal amino group (Boc- or Z- protection). Different protecting groups were used to exchange the position and number of bounded peptide. Modifications were performed in intention to increase biological activity of quercetine as well as enkephalins which also examine antitumor activity. Antitumor evaluation and interactions with ct-DNA of prepared compounds were investigated.

Quercetin ; Biological Activity ; Enkephalin

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

123-123.

2010.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Journal of peptide science

Moroder, Luis

Chichester: John Wiley & Sons

1075-2617

Podaci o skupu

31st European Peptide Symposium

poster

05.09.2010-09.09.2010

Kopenhagen, Danska

Povezanost rada

Kemija

Indeksiranost