engleski

Systemic inflammatory response syndrome and multiple organ dysfunction syndrome in canine babesiosis

Canine babesiosis caused by Babesia canis canis is one of the commonest canine diseases in Croatia, especially in the area of capital city Zagreb. Babesiosis is a multi-system disease and multiple organ dysfunction syndrome (MODS) develops from systemic inflammatory response syndrome (SIRS) which is a hallmark of babesiosis. Therefore, the purpose of this study was to conduct a detailed research of incidence of SIRS and MODS as well as organ systems involvement on large number of dogs naturally infected with B. canis canis in Croatia. Out of 332 dogs with canine babesiosis, 226 dogs (68 percent) fullfiled the SIRS criteria and were considered as SIRS positive. Among them 151 dogs (67%) fulfilled two SIRS criteria, 66 dogs (29%) fulfilled three criteria and only 9 dogs (4%) fulfilled all four SIRS criteria. Thirty three dogs (10%) fulfilled the MODS criteria. Among them 22 dogs (66%) had two organ involvement, 10 dogs (31%) had three organ involvement and in only 1 dog (3%) four organs dysfunction was present. The incidence of organ involvement in MODS were as follows: renal dysfunction (30/33), liver dysfunction (20/33), muscle involvement (19/33), lung dysfunction (16/33), cerebral involvement (3/33). Among MODS positive dogs, 22 dogs died and 11 dogs survived babesiosis. In dogs with two organ involvement survival was 45%, in dogs with three organ involvement survival was 10%, while in the group with four organ dysfunction mortality was 100%. It can be concluded in cases of canine babesiosis caused by B. canis canis, in which MODS developed, an unfavourable outcome should be taken in consideration.

babesiosis; dog; systemic inflammatory response syndrome; multiple organ dysfunction syndrome

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