engleski

ARE SERUM LIPIDS MEASURED ON STROKE ADMISSION PROGNOSTIC?

Background: It has been hypothesized that serum lipids measured in early period of stroke are predictive of stroke severity and outcome. Th e optimal time for lipid measurement is not established. We explored whether lipid profi le assesses within the fi rst 24 hours after stroke onset: (i) diff ers from healthy individuals ; (ii) diff ers between stroke subtypes and (iii) is predictive of stroke severity and outcome. Methods: We prospectively enrolled 70 acute ischemic stroke patients who presented to the Stroke Unit within the 24 hours of the onset of stroke symptoms, and 68 stroke-free controls. Results: Triglycerides (p<0.001) and HDL cholesterol (p<0.001) were signifi cantly lower in patients, than in controls, wheres Apo B/Apo A-I ratio was higher in patients (P=0.019). HDL cholesterol was diff erent across stroke subtype classifi ed according to TOAST scale (P=0.035). Patients with more severe stroke had higher serum triglycerides (OR 2.755 ; P=0.030). Conclusion: Lipid profi le is diff erent between stroke patients and controls as well as between stroke subtypes. Higher serum concentration of triglycerides is associated with more severe stroke. Further work is required to examine the time dependent changes in lipid profi le in acute ischemic stroke. If proven to have ome predictive role on a larger patient cohort, blood profi le may serve as useful aid in managment of acute stroke patient care.

Lipid profile; stroke

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