A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties (CROSBI ID 569124)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Slavuljica, Irena ; Busche, Andreas ; Babić, Marina ; Mitrović, Maja ; Gašparović, Iva ; Cekinović, Đurđica ; Markova Car, Elitza ; Pernjak Pugel, Ester ; Ciković, Ana ; Juranić Lisnić, Vanda ; Britt, William J. ; Koszinowski, Ulrich ; Messerle, Martin ; Krmpotić, Astrid ; Jonjić, Stipan
engleski
A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties
The authors propose a model where an engineered cytomegalovirus serves as a potential vaccine. Namely, a ligand for the strong activating NK cell receptors is inserted into a CMV-BAC, and this feature makes the virus strongly attenuated in vivo in both immunocompetent and immunodeficient hosts. Infection of mice with this virus however elicited strong, long-lasting protective immunity.
MCMV; NKG2D; CMV vaccine
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Podaci o prilogu
21-21.
2010.
objavljeno
Podaci o matičnoj publikaciji
Annual meeting of the Austrian Society for Allergology and Immunology-Book of abstracts
Beč:
Podaci o skupu
Annual Meeting of the Austrian Society for Allergology and Immunology
poster
03.10.2010-05.10.2010
Beč, Austrija
