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The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against both the adaptive and innate immune response (CROSBI ID 475868)

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Krmpotić, Astrid ; Messerle, Martin ; Crnković-Mertens, Irena ; Bubić, Ivan ; Hengel, Hartmut ; Jonjić, Stipan ; Koszinowski, Ulrich The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against both the adaptive and innate immune response // Annual meeting of the Croatian Immunological Society / Rabatić, Sabina (ur.). Zagreb: Hrvatsko imunološko društvo, 1999. str. 5-x

Podaci o odgovornosti

Krmpotić, Astrid ; Messerle, Martin ; Crnković-Mertens, Irena ; Bubić, Ivan ; Hengel, Hartmut ; Jonjić, Stipan ; Koszinowski, Ulrich

engleski

The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against both the adaptive and innate immune response

Cytomegaloviruses encode numerous products that inhibit antigen presentation in the MHC class I pathway in vitro. The mouse cytomegalovirus (MCMV) glycoprotein gp40, encoded by the m152 gene retains murine MHC class I complexes in the ERGIC/cis-Golgi compartment (Ziegler et al., Immunity 6:57, 1997). To investigate the in vivo significance of this gene function during MCMV infection of the natural host, we constructed recombinants of MCMV in which the m152 gene was deleted, as well as the corresponding virus revertants. Deletion of the m152 gene has no effect on virus replication in cell culture, whereas after infection of mice the m152 deficient virus replicates to significantly lower virus titers. This attenuating effect is lifted by reinsertion of the gene into the mutant. Mutants and revertants grow to the same titer in mice deficient for MHC-class I effector function. These results prove that MHC reactive functions protect cytomegaloviruses against the attack by CD8+ T lymphocytes in vivo (Krmpotić et al., J. Exp. Med. 190:1285, 1999). In addition, the m152 deletion affects virus control by NK cells in vivo. However, contrary to the expected, the deletion of the m152 function, although associates with increased MHC class I expression, renders the virus more sensitive to NK cells. This NK cell sensitizing effect is mouse strain specific. Since infected cells from responder and nonresponder strains are recognized, specificity is defined at the level of the NK cell receptor. In conclusion, we showed for the first time that a herpesvirus protein can downmodulate both the adaptive and the innate immune.

cytomegalovirus; m152 gene; T cells; NK cells

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Podaci o prilogu

5-x.

1999.

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objavljeno

Podaci o matičnoj publikaciji

Annual meeting of the Croatian Immunological Society

Rabatić, Sabina

Zagreb: Hrvatsko imunološko društvo

Podaci o skupu

Annual meeting of the Croatian Immunological Society 1999

poster

25.11.1999-25.11.1999

Zagreb, Hrvatska

Povezanost rada

Temeljne medicinske znanosti