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Setting research priorities to reduce almost one million deaths from birth asphyxia by 2015 (CROSBI ID 168062)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lawn, Joy E. ; Bahl, Rajiv ; Bergstrom, Staffan ; Bhutta, Zulfiqar A. ; Darmstadt, Gary L. ; Ellis, Matthew ; English, Mike ; Kurinczuk, Jennifer J. ; Lee, Anne C. C. ; Merialdi, Mario et al. Setting research priorities to reduce almost one million deaths from birth asphyxia by 2015 // PLoS medicine, 8 (2011), 1; e1000389, 11. doi: 10.1371/journal.pmed.1000389

Podaci o odgovornosti

Lawn, Joy E. ; Bahl, Rajiv ; Bergstrom, Staffan ; Bhutta, Zulfiqar A. ; Darmstadt, Gary L. ; Ellis, Matthew ; English, Mike ; Kurinczuk, Jennifer J. ; Lee, Anne C. C. ; Merialdi, Mario ; Mohamed, Mohamed ; Osrin, David ; Pattinson, Robert ; Paul, Vinod ; Ramji, Siddarth ; Saugstad, Ola D. ; Sibley, Lyn ; Singhal, Nalini ; Wall, Steven N. ; Woods, Dave ; Wyatt, John ; Chan, Kit Yee ; Rudan, Igor

engleski

Setting research priorities to reduce almost one million deaths from birth asphyxia by 2015

Intrapartum-related neonatal deaths (previously called ‘birth asphyxia’) are the fifth most common cause of deaths among children under 5 years of age, accounting for an estimated 814, 000 deaths each year, and also associated with significant morbidity, resulting in a burden of 42 million disability adjusted life years (DALYs). This paper uses a systematic process developed by the Child Health Nutrition Research Initiative (CHNRI) to define and rank research options to reduce mortality from intrapartum-related neonatal deaths by the year 2015, in order to advance Millennium Development Goal(MDG) 4 for child survival. A list of 61 research questions was developed and scored by 21 technical experts. The top one-third of the ranked research investment options was dominated by delivery (implementation) research, whilst discovery (basic science) questions were not ranked highly, especially for expected reduction of mortality and inequity in the short time to 2015. Among the top four research questions, two relate to generation of demand for facility care at birth with specific mechanisms (such as transport and communication schemes, or financial incentives and conditional cash transfers). The other two top ranked priorities relate to use of community cadres and the roles they might effectively play—for example, screening for complications or supportive transfer to facilities and companionship at birth. The highest ranked discovery question concerned the interaction of hypoxia and infection, and the highest ranked epidemiologic question addressed prediction of intrapartum hypoxic injury. This exercise highlights the need for current research investments to focus on studies most likely to result in accelerated progress towards MDG 4 and in the countries where the most deaths occur.

priority setting ; health research ; CHNRI methodology ; guidelines ; birth asphyxia

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Podaci o izdanju

8 (1)

2011.

e1000389

11

objavljeno

1549-1277

1549-1676

10.1371/journal.pmed.1000389

Povezanost rada

Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, Temeljne medicinske znanosti

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