Ispitivanje antioksidativne aktivnosti hidroksamskih kiselina (CROSBI ID 362496)
Ocjenski rad | diplomski rad
Podaci o odgovornosti
Petrić, Neva
Zovko Končić, Marijana
hrvatski
Ispitivanje antioksidativne aktivnosti hidroksamskih kiselina
In the present study, seven hydroxamic acid derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen, indomethacin and diclofenac) were found to possess significant antioxidant, radical scavenging and metal chelating activities. The most active antioxidant and radical scavenger was N-methylhydroxamic acid of diclofenac (ANT = 88.0 % and EC50 = 60.1 mg mL– 1). The activity of the standard substance, butylated hydroxyanisole, in the two assays was ANT = 86.9 % and EC50 = 18.8 mg mL– 1, respectively. Ibuproxam was the strongest iron chelator among investigated hydroxamic acids (EC50 = 255.6 mg mL– 1), yet significantly weaker than the standard substance, EDTA (EC50 = 29.1 mg mL– 1). It seems that different mechanism is involved in metal chelating activity than in antioxidant and radical scavenging activity. Antioxidant and radical scavenging activities may be connected with conjugation of the nitrogen lone electron pair with the carbonyl group. On the other hand, more hydrophilic substances tend to be better iron chelators.
antioksidativna aktivnost; hidroksamske kiseline; antiradikalna aktivnost; beta-karoten linoleatni test
nije evidentirano
engleski
Antioxidant activity of hydroxamic acid
nije evidentirano
antioxidant activit; y hydroxamic acid; antiradical activity; beta-carotene linoleate assay
nije evidentirano
Podaci o izdanju
25
15.06.2009.
obranjeno
Podaci o ustanovi koja je dodijelila akademski stupanj
Farmaceutsko-biokemijski fakultet
Zagreb