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Liver regeneration in perforin-deficient mice (CROSBI ID 475975)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Radošević-Stašić, Biserka ; Trobonjača, Zlatko ; Ravlić-Gulan, Jagoda ; Ćuk, Mira ; Mrakovčić-Šutić, Ines ; Rukavina, Daniel Liver regeneration in perforin-deficient mice // Programme, Abstacts / Hrvatsko imunološko društvo (ur.). Zagreb: Hrvatsko imunološko društvo, 1999. str. P22.-x

Podaci o odgovornosti

Radošević-Stašić, Biserka ; Trobonjača, Zlatko ; Ravlić-Gulan, Jagoda ; Ćuk, Mira ; Mrakovčić-Šutić, Ines ; Rukavina, Daniel

engleski

Liver regeneration in perforin-deficient mice

To test the possible role of cytotoxic T and NK cells in the control of normal growth in this study the liver regeneration was analyzed in perforin knock out (PKO) mice, which have normal numbers of CD8+ and NK+ cells, but owing to the lack of a key effector molecule are unable to lyze the transformed targets. The data showed that 24 hours and 7 days after 1/3 pHx in regenerating liver of wild mice the percentage of cells in G2/M phase increased. In contrast to this, PKO mice, had initially smaller (on 1st day) and then greater (at 3rd and 7th day ) fraction of cells in G2+M phase of cell cycle, suggesting that the response to pHx in the PKO mice was significantly delayed, and implying the local role of T and/or NK-cell mediated cytolytic mechanisms in the control of liver

liver regeneration; perforin-deficient mice

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Podaci o prilogu

P22.-x.

1999.

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objavljeno

Podaci o matičnoj publikaciji

Programme, Abstacts

Hrvatsko imunološko društvo

Zagreb: Hrvatsko imunološko društvo

Podaci o skupu

Annual meeting of the Croatian Immunological Society 1999

poster

25.11.1999-25.11.1999

Zagreb, Hrvatska

Povezanost rada

nije evidentirano