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Synthesis and antitumor activity of novel benzimidazoles and benzimidazo[1, 2-a]quinolines

Over the past few years substituted benzimidazoles and their azino fused derivatives have been one of the most extensively studied classes of heterocyclic compounds and the constant and growing interest for their synthesis is owed mostly to their well known biological activities. Besides the fact that benzimidazoles are widely incorporated in the structure of numerous important medical and biochemical agents, they have the structural similarity with some naturally occurring compounds such as purine and can easily interact with biomolecules of the living systems [1, 2]. This work presents, as a part of our continuing research in the field of medicinal chemistry, the synthesis of novel nitro- and amino-substituted benzimidazoles and benzimidazo[1, 2-a]quinolines as a potential biologically active agents [3]. Antitumor activity in vitro of prepared compounds was tested on several human tumour cell lines. All tested compounds showed strong antiproliferative effect on most tested cell lines derived from different cancer types.

benzimidazoles; benzimidazo[1; 2-a]quinolines; antitumor activity

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