Synthesis of novel N-sulfonylamidines in pyrimidine series (CROSBI ID 571049)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Krstulović, Luka ; Bajić, Miroslav ; Višnjevac, Aleksandar ; Žinić, Biserka
engleski
Synthesis of novel N-sulfonylamidines in pyrimidine series
Amidines are found in many bioactive natural products [1] and identified as important pharmacophores [2]. Novel N-sulfonylamidines in pyrimidine series were utilized as a part of continous research on potential biologically active compounds. Synthesis involves three component, one-pot, copper catalyzed reaction of terminal alkyne, sulfonyl azide and amine. The reaction is propose to proceed via the formation of ketenimine intermediate, which is generated in situ by the Cu-catalyzed cycloaddition of sulfonyl azide with terminal alkynes followed by the ring opening of resultant triazole copper intermediate which reacts with amine to give three-component coupled product[3]. The structure of all compounds was confirmed on the basis of 1H, 13C NMR spectra and elemental analysis. Analysis by 2D NMR experiments confirmed anti-conformations of the products in DMSO solution and the same conformation was found by X-ray diffraction studies of some compounds. These products are under investigation for their biological activities.
N-sulfonylamidines ; pyrinidines
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Podaci o prilogu
41-41.
2011.
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objavljeno
978-953-6894-38-3
Podaci o matičnoj publikaciji
Book of abstracts, XXII. Hrvatski skup kemičara i kemijskih inženjera
Pičuljan, Katarina ; Smolec, Sonja
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
Podaci o skupu
XXII.Hrvatski skup kemičara i kemijskih inženjera
predavanje
13.02.2011-16.02.2011
Zagreb, Hrvatska