engleski

Genetic interactions in the renin-angiotensin system confer increased risk of stroke.

Background: Stroke is a polygenic and multifactorial atherothrombotic disease. The renin-angiontensin system has an importan role in cerebrovascular disease through a variety of processes. The angiotensin-converting enzyme converts angiotensin I into angiotensin II, which binds the angiotensin II type-1 receptor and is a potent vasoconstrictor. Both ACE I/D and AT1R A1166C polymorphisms lead to an enhanced activity of the angiotensin II-AT1R axis, thereby possibly contributing to circulatory disturbances. The aim of our study was to investigate ACE I/D and AT1R A1166C polymorphism and the risk of stroke. Methods and materials: Clinical data and genetic and biochemical parameters of 84 patients, aged 30 to 60 years, with acute ischemic stroke were analyzed. A total of 76 controls matched for antropometric parameters, but were carotide ultrasonography alterations-free, older at lest ten years than patients and without history of stroke before age of 70 in two generations. DNA was genotyped for ACE I/D and AT1R A1166C polymorphism. Results: 51, 45 and 41 % of patients had elevated cholesterol, triglycerides and blood pressure respectively. The ACE D allele combined with the AT1R 1166C allele did not yield a risk of ischemic stroke. However, the co-occurrence of the homozygous ACE D/D and at least one AT1R 1166C allele was more frequent in the ischemic stroke group of patients under the age of forty than in the control group (22.4 vs 11%, p < 0.03, OR, 2.33 ; 95% CI, 1.46-3.7). Conclusion: ACE D/D and AT1R 1166C polymorphism could be risk factor for early occurance of stroke.

renin-angiotensin system; stroke

nije evidentirano