engleski

Oxidative Stress and Reproductive Disorders in Dairy Cows - a Proteomic Challenge

Reproductive diseases including cystic ovarian follicles, subfertility, retained placenta and metritis present a great problem in dairy cows management. Although ROS are unavoidable products of normal metabolic processes and are not always harmful, they can impair health and the reproductive performance of dairy cows. At the protein level, both proteins expression and their modification are affected by oxidative stress. In particular, oxidative modifications of steroidogenic enzymes and steroid hormones modulate their function and directly impair reproduction leading to reproductive disorders including an increased interval to first estrus, poor oocyte quality and weak estrus expression making the detection of estrus even more difficult. Most of our knowledge on oxidative stress has been obtained using conventional biochemical methods. However, proteomic analysis could allow studying oxidative stress response on a much wider magnitude including both variations in protein expression and protein oxidative modification. Clear understanding of the pathophysiology of oxidative stress could contribute to a better approach to reproductive management of dairy cows avoiding reproductive diseases as much as possible.

oxidative stress; dairy cows; reproduction; paraoxonase 1

nije evidentirano