engleski

IRON HOMEOSTASIS MARKERS AND C-REACTIVE PROTEIN (CRP) IN PATIENTS WITH STABLE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Background. The goal of the study was to determine changes in iron homeostasis factors and CRP in patients with stable COPD. ROC analysis was done to investigate the diagnostic efficiency of selected biochemistry analytes in discriminating between COPD patients and healthy individuals. Methods.The study included 109 COPD patients (FEV1=41±14%) and 51 healthy examinees (FEV1=106±15%). Following GOLD guidelines, patients were divided into subgroups II, III, IV. CRP concentration was determined by an immunoturbidimetric method while iron and TIBC concentrations were found using the ferene colorimetric method on a Dimension Xpand Plus analyzer. Ferritin concentration was determined using CMIA technology on an Architect 12000sr immunoanalyzer, TfR concentration by the immunoturbidimetric method on an Olympus AU2700 analyzer and EPO concentration by the ELISA method. Results. UIBC and TIBC concentrations were significantly lower in COPD patients (p<0.0001, p=0.0002) and in GOLD subgroups (p<0.0001, p=0.001). Iron concentration was significantly higher only in GOLD IV subgroup (p=0.004). Ferritin and CRP concentrations were twofold higher in patients and all GOLD subgroups (p<0.0001) than in controls. ROC analysis in COPD patients and control group indicated good discriminatory efficiency of UIBC, ferritin and CRP but did not show good diagnostic accuracy in differentiation between GOLD subgroups. Conclusions. Iron concentration was significantly higher in the GOLD IV subgroup involving the most severe form of the disease, indicating significant redistribution of iron in severe forms of pulmonary diseases. CRP concentration was significantly higher in all COPD subgroups and confirmed CRP to be a marker of systemic inflammation in COPD patients.

iron homeostasis; COPD; CRP

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