Update on immunopathogenesis of psoriasis (CROSBI ID 573285)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Kaštelan, Marija
engleski
Update on immunopathogenesis of psoriasis
Psoriasis is a common chronic inflammatory skin disease characterized by hyperproliferation and incomplete differentiation of epidermal keratinocytes. It is nowadays also recognized as a T-cell mediated disease resulting from aberrant activation of both, innate and adaptive immunity. The dysregulation of innate immunity provides an initial signal for the activation of specific effectors cells namely Th1 and Th17 cells. Recent studies indicate the role of IL23/ Th17 axis as a key mechanism in the evolution of psoriatic plaques. Thus, interplay between keratinocytes and immune cells in the patients who have genetic predisposition orchestrate the complex cascade of events leading to the development of psoriatic lesions. Finally, the subsequent impact of the postulated new immunopathogenetic mechanisms in psoriasis on the development and efficacy of the novel biological therapies is highlighted.
Psoriasis; Imunnopathogenesis
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Podaci o prilogu
2011.
objavljeno
Podaci o matičnoj publikaciji
4th Congress of Croatian Dermatovenereologists with International Participation - Abstract Book
Podaci o skupu
4. kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem
pozvano predavanje
05.05.2011-08.05.2011
Osijek, Hrvatska