engleski

Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides

A novel class of mannosylated adamantyltripeptides, general formula of which is α-Man-OCH2CH(CH3)CO-AdGly-L-Ala-D-isoGln, were prepared, characterized, and their possible immunomodulatory properties investigated in some preliminary tests in vivo. All newly synthesized glycopeptides comprise in their structure the adamantylglycyl moiety linked to the dipeptide L-Ala-D-isoGln, as well as mannose. Adjuvant activity of mannosylated adamant-2-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala).

O-mannopyranosides; adamantyltripeptides; peptidoglycan monomer; immunomodulation

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