engleski

Oxidized DNA in patients with post-traumatic stress disorder

Background. Post-traumatic stress disorder (PTSD) is an anxiety disorder developed after a traumatic experience. Considering that free radicals mediate neuronal damage in several psychiatric disorders, we wanted to investigate the possible difference in the concentration of oxidized DNA (8-hydroxy- 2`-deoxyguanosine, 8-OHdG) as most significant marker of DNA oxidative damage in PTSD patients in comparison to the healthy control group. Methods. The study included 47 male PTSD patients with a median age of 42 (32 - 62), and 43 healthy male controls with a median age of 39 years (31 - 58). Oxidized DNA was determined in urine samples of both patients and controls using ELISA kit (Bühlmann, Schönenbuch, Switzerland). Results. The median value of 8-OHdG in the urine samples of PTSD group was 75 ng/ml (29 - 320) and in the control group 8-OHdG concentration was 87 ng/ml (27, 5 - 160). Mann-Whitney test did not show statistically significant difference between values for 8-OHdG between the studied groups (P=0, 726). Conclusions. Our results show that oxidative damage of DNA molecule in PTSD group did not differ from healthy control group. Considering that literature data suggest that other anxiety disorders like obsessive-compulsive disorder could be related to free radicals influence, our results contribute to the efforts to biologically differentiate PTSD from other anxiety disorders.

Post-traumatic stress disorder; oxidized DNA

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