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The evidence of proinflammatory and prothrombotic role of leptin receptor gene

Aims: In this study we investigated association of the common polymorphic variants in the LEPR gene with obesity, serum lipids and inflammatory markers C-reactive protein (CRP) and fibrinogen. The leptin receptor, encoded by the LEPR gene, is a single transmembrane protein that exerts the function of leptin, the protein that is known to regulate food intake, energy homeostasis, reproductive and immune function. Methods: We selected 32 single nucleotide polymorphisms (SNP) in/near LEPR gene from genome-wide association study data (Human Hap300 Illumina platform) from Vis cohort (N = 986), including two commonly investigated SNPs: Arg109Lys and Arg223Gln. Association of polymorphisms with anthropometric measures of obesity, concentration of serum lipids, CRP and fibrinogen was tested using analysis of variance and logistic regression analysis. Results: Several SNPs in intron 2 region were clearly associated with serum lipids and only marginally with anthropometric measures of obesity, while SNPs near the 3’ region of the gene correlated significantly with fibrinogen and HDL. Conclusion: Analyzed SNPs of LEPR gene were generally not found to be significant predictors of obesity in contrast to their marked involvement in lipid metabolism. Moreover, our results suggest an important proinflammatory and prothrombotic role of leptin signaling system.

LEPR; obesity; inflammation; fibrinogen; Vis cohort

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