β-BUTIROLACTONES WITH ADAMANTANE MOIETY SEARCHING FOR NOVEL BIOACTIVE β-LACTONES (CROSBI ID 575143)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Matković, Marija ; Mlinarić-Majerski, Kata
engleski
β-BUTIROLACTONES WITH ADAMANTANE MOIETY SEARCHING FOR NOVEL BIOACTIVE β-LACTONES
Alongside the well known β-lactams, literature also describes their O-analogs, β-lactons, as structural entities that bring up biological activity. Furtheron, β-lactons are usefull precursors in organic synthesis such as in the preparation of allenes or β-aminoacids. Therefore the convenient synthetic route of preparing these interesting four memberd heterocycles, differently substituted, has occurred as an object of investigation. The fact that the adamantane moiety is present as a pharmacophoric group in different therapeutic agents makes idea of preparing adamantyl-substituted β-lactones quite intriguing. Herein we present a simple method of preparing adamantyl-substituted β-butyrolactones 1 and 2 as well as their structural elucidation. The reactivity of these molecules towards the ring opening will also be discussed.
β-aminoacids; adamantyl-substituted β-butyrolactones and β-lactones
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Podaci o prilogu
216-x.
2011.
objavljeno
Podaci o matičnoj publikaciji
4th European Conference on Chemistry for Life Sciences / 4ECCLS
Budimpešta:
Podaci o skupu
4th European Conference on Chemistry for Life Sciences / 4ECCLS
poster
31.08.2011-03.09.2011
Budimpešta, Mađarska