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β-BUTIROLACTONES WITH ADAMANTANE MOIETY SEARCHING FOR NOVEL BIOACTIVE β-LACTONES (CROSBI ID 575143)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Matković, Marija ; Mlinarić-Majerski, Kata β-BUTIROLACTONES WITH ADAMANTANE MOIETY SEARCHING FOR NOVEL BIOACTIVE β-LACTONES // 4th European Conference on Chemistry for Life Sciences / 4ECCLS. Budimpešta, 2011. str. 216-x

Podaci o odgovornosti

Matković, Marija ; Mlinarić-Majerski, Kata

engleski

β-BUTIROLACTONES WITH ADAMANTANE MOIETY SEARCHING FOR NOVEL BIOACTIVE β-LACTONES

Alongside the well known β-lactams, literature also describes their O-analogs, β-lactons, as structural entities that bring up biological activity. Furtheron, β-lactons are usefull precursors in organic synthesis such as in the preparation of allenes or β-aminoacids. Therefore the convenient synthetic route of preparing these interesting four memberd heterocycles, differently substituted, has occurred as an object of investigation. The fact that the adamantane moiety is present as a pharmacophoric group in different therapeutic agents makes idea of preparing adamantyl-substituted β-lactones quite intriguing. Herein we present a simple method of preparing adamantyl-substituted β-butyrolactones 1 and 2 as well as their structural elucidation. The reactivity of these molecules towards the ring opening will also be discussed.

β-aminoacids; adamantyl-substituted β-butyrolactones and β-lactones

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Podaci o prilogu

216-x.

2011.

objavljeno

Podaci o matičnoj publikaciji

4th European Conference on Chemistry for Life Sciences / 4ECCLS

Budimpešta:

Podaci o skupu

4th European Conference on Chemistry for Life Sciences / 4ECCLS

poster

31.08.2011-03.09.2011

Budimpešta, Mađarska

Povezanost rada

Kemija