Lipase-catalyzed kinetic resolution of racemic 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates (CROSBI ID 174362)
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Podaci o odgovornosti
Brem, Jürgen ; Toşa, Monica-Ioana ; Paizs, Csaba ; Munceanu, Anca ; Matković-Čalogović, Dubravka ; Irimie, Florin-Dan
engleski
Lipase-catalyzed kinetic resolution of racemic 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates
The synthesis of both enantiomers of 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates by enantiomer-selective acylation of racemic alcohols with the lipase from Pseudomonas fluorescens (L-AK) or/and by methanolysis of the corresponding racemic esters with lipase B from Candida antarctica (CaL-B) is described. The absolute configuration of the enantiomerically pure enantiomers was determined by X-ray crystallography.
kinetic resolution; lipase; X-ray crystallography
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