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izvor podataka: crosbi

Odor identification and cognitive abilities in Alzheimer's disease (CROSBI ID 174409)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Tkalčić, Mladenka ; Spasić, Nika ; Ivanković, Matea ; Pokrajac-Bulian, Alessandra ; Bosanac, Daša Odor identification and cognitive abilities in Alzheimer's disease // Translational Neuroscience, 2 (2011), 3; 233-240. doi: 10.2478/s13380-011-0026-1

Podaci o odgovornosti

Tkalčić, Mladenka ; Spasić, Nika ; Ivanković, Matea ; Pokrajac-Bulian, Alessandra ; Bosanac, Daša

engleski

Odor identification and cognitive abilities in Alzheimer's disease

Research results indicate systemic odor identification deficits in patients with Alzheimer's disease (AD). The aims of this study were: 1) to compare the ability to identify different odors and to compare cognitive status among patients with AD, patients with vascular dementia (VaD) and a comparison group of elderly persons ; 2) to test the efficiency of olfactory and neuropsychological measures to classify patients and 3) to relate the odor identification ability with cognitive functioning for each group, respectively. The participants were 15 patients with AD, 11 patients with VaD and 30 non-demented elderly persons, age range 58 to 90. To assess olfactory function, we used the Scandinavian Odor-Identification Test. To assess cognitive functions, we used the Dementia Rating Scale-2, the Clock Drawing Test, the Boston Naming Test and the Category Fluency Test. The ANOVA showed that patients with AD correctly identifed significantly fewer odors presented to them compared to patients with VaD and control group. Patients with AD achieved significantly lower scores on all neuropsychological measures compared to the control group and differ in the DRS-2 total score, initiation/perseveration, constructive and naming abilities comparing to patients with VaD. Discriminant analysis showed that category fluency and olfactory identification were the best predictors of AD. Significant correlations were found between the olfactory and initiation/perseveration, memory and animal naming abilities for patients with AD. Differences among patients with AD, VaD and elderly persons exist in their abilities to identify odors. The findings suggest that olfactory functional testing in combination with memory testing are important.

odor identification ; cognitive abilities ; Alzheimer’s disease ; vascular dementia ; non-demented elderly persons

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Podaci o izdanju

2 (3)

2011.

233-240

objavljeno

2081-3856

2081-6936

10.2478/s13380-011-0026-1

Povezanost rada

Kliničke medicinske znanosti, Psihologija

Poveznice
Indeksiranost