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Pregled bibliografske jedinice broj: 530715

Časopis

Autori: Šarac, Helena; Hajnšek, Sanja; Bašić, Silvio; Telarović, Srđana; Markeljević, Jasna; Vukić, Miroslav; Radoš, Marko; Bošnjak-Pašić, Marija; Žarković, Kamelija; Hof, Patrick R.; Šimić, Goran
Naslov: Giant cavernoma of the skull and skeletal-extraskeletal angiomatosis associated with paraproteinemia
Izvornik: Translational Neuroscience (2081-3856) 2 (2011), 3; 265-269
Vrsta rada: članak
Ključne riječi: cavernoma; hemangioma; monoclonal gammopathy; skeletal-extraskeletal angiomatosis; skull; paraproteinemia
Sažetak:
Skeletal-extraskeletal angiomatosis is defined as a benign vascular proliferation affecting the medullar cavity of the bone and at least one other type of tissue, including skin, subcutaneous tissue, viscera, muscle, or synovium, and which does not spread to avascular tissue such as cartilage. Primary hemangiomas/ cavernous hemangiomas (cavernomas) are exceedingly rare in the skull, accounting for 0.2% of all osseous neoplasms and are usually located in frontal and parietal bones. The authors present the case of a 66-yearold man who was admitted with right-side hemiparesis. MRI revealed a destructive bone lesion of the left frontal bone. Digital subtraction angiography of the brain did not reveal pathological vascularization, but a minor submucous hemangioma was seen in the nasal airway. Urine test for Bence-Jones proteins was positive for IgG λ light chain. Bone marrow aspiration and CSF analysis revealed no evidence of systemic myelomatosis suggesting a monoclonal gammopathy of undetermined significance. A highly vascular tumor was surgically removed. The histopathology verified cavernous hemangioma of the skull and the nasal submucous hemangioma. We discuss the diagnostic procedure, possible pathophysiological mechanisms and treatment implementation. It is possible that immunoglobulins from monoclonal gammopathies have an etiologic role in the development of the bone and skin changes in older patients, as an acquired condition, by producing a vascular injury that could lead to the multiple hemangiomas in skeletal-extraskeletal angiomatosis. To prevent misdiagnosis with lesions of other origins, multiple lesions of the head must be resected and histopathologically verified. In conclusion, to the best of our knowledge, this is the first case of giant cavernous hemangioma of the skull associated with paraproteinemia and skeletalextraskeletal angiomatosis limited to the head.
Projekt / tema: 108-1081870-1942, 108-1080231-0024
Izvorni jezik: ENG
Current Contents: NE
Citation Index: NE
Ostale indexne publikacije: EMBASE (Excerpta Medica)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
Tiskani medij: da
URL Internet adrese: http://www.springerlink.com/content/8140205874667p16/
Broj citata:
Altmetric:
DOI: 10.2478/s13380-011-0032-3
Google Scholar: Giant cavernoma of the skull and skeletal-extraskeletal angiomatosis associated with paraproteinemia
Upisao u CROSBI: gsimic@mef.hr (gsimic@mef.hr), 18. Lis. 2011. u 10:45 sati



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