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Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat (CROSBI ID 175845)

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Pavlinac Dodig, Ivana ; Pecotić, Renata ; Valić, Maja ; Đogaš, Zoran Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat // Journal of sleep research, 21 (2012), 2; 195-203. doi: 10.1111/j.1365-2869.2011.00948.x

Podaci o odgovornosti

Pavlinac Dodig, Ivana ; Pecotić, Renata ; Valić, Maja ; Đogaš, Zoran

engleski

Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat

Obstructive sleep apnea (OSA) is characterized by periods of upper airway collapse accompanied by repeated episodes of hypoxia. In experimental animals repeated bouts of hypoxia may evoke sustained augmentation of phrenic nerve activity, known as phrenic long term facilitation (pLTF). This form of physiological compensation might contribute to a stable breathing minimizing the occurrence of apneas and/or hypopneas during sleep in patients with OSA. Serotonin (5-HT) has been shown to modulate respiratory neuronal activity, possibly via projections originating in the raphe nuclei. Our model focuses on effects of 5-HT1A receptors blockade by selective antagonist WAY-100635 into the caudal raphe region on phrenic long term facilitation after exposure to acute intermittent hypoxia (AIH) episodes. Adult, male, urethane- anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats were exposed to AIH protocol. Experimental group received microinjection of WAY-100635 into the caudal raphe nucleus, whereas control group received saline into the same site. Peak phrenic nerve activity and respiratory rhythm parameters were analyzed during five hypoxic episodes, as well as at 15, 30, and 60 minutes after the end of hypoxias. In the control group, one hour post-hypoxia pLTF was developed. Microinjections of selective 5-HT1A receptor antagonist WAY- 100635 into the raphe nuclei prior to AIH protocol prevented induction of pLTF. These results suggest that 5-HT1A receptor activation at supraspinal level is important for induction of pLTF which is suggested to be an important respiratory neuroplasticity model in animal studies that possibly correlates with OSA in humans.

serotonin; phrenic nerve; long term facilitation; respiratory plasticity; sleep apnea

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Podaci o izdanju

21 (2)

2012.

195-203

objavljeno

0962-1105

10.1111/j.1365-2869.2011.00948.x

Povezanost rada

Temeljne medicinske znanosti

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