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Predicted coronary heart disease risk in croatian HIV infected patients treated with combination antiretroviral therapy (CROSBI ID 175861)

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Turčinov, Drago ; Begovac, Josip Predicted coronary heart disease risk in croatian HIV infected patients treated with combination antiretroviral therapy // Collegium antropologicum, 35 (2011), 1; 115-121

Podaci o odgovornosti

Turčinov, Drago ; Begovac, Josip

engleski

Predicted coronary heart disease risk in croatian HIV infected patients treated with combination antiretroviral therapy

We assessed the coronary heart disease (CHD) risk in 130 HIV-infected patients with no major past cardiovascular event treated with combination antiretroviral therapy (CART) between May 2004 and June 2005. We also investigated the association of HIV disease parameters (CD4 + T-cell counts, HIV viral load, AIDS diagnosis, antiretroviral medications and lipodystrophy), demographics, anthropometrics, clinical features, smoking status, dyslipidemia, adherence to the Mediterranean diet, and the metabolic syndrome (MS) to the Framingham risk score. The median 10-year CHD risk was 6.4% (IQR 3.3-13.0) for males and 1.8% (IQR 1.0-6.7) for females. The CHD risk was > or = 10% in 31.1% (32 of 103) males and in 14.8% (4 of 27) females. MS was present in 27 (20.8%) individuals. Participants who met the definition of the MS had a 2.63 times greater chance of having a CHD risk 210% (95% CI, 1.09-6.39 ; p = 0.032). On multivariable analysis, we found that a CHD risk > or = 10% was associated with: a lowest ever CD4+ T-cell counts of less than 50 per microliter and a past history of AIDS (OR, 6.26 ; 95% CI, 1.61-24.36 ; p = 0.008) ; alcohol consumption 210 g/day (OR, 3.87 ; 95% CI, 1.56-14.22 ; p = 0.041) ; and age 243 years (OR, 1.30 ; 95% CI, 1.17-1.45 ; p < 0.001). Interventions to reduce the modifiable cardiovascular risk are needed in Croatian patients treated with CART.

HIV; coronary heart disease; Framingham risk score; metabolic syndrome

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Podaci o izdanju

35 (1)

2011.

115-121

objavljeno

0350-6134

Povezanost rada

Kliničke medicinske znanosti

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