A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK) (CROSBI ID 176175)
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Podaci o odgovornosti
Krištafor, Svjetlana ; Novaković, Ivana ; Gazivoda Kraljević, Tatjana ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Westermaier, Yvonne ; Pernot, Lucile ; Scapozza, Leonardo ; Ametamey, Simon M. ; Raić-Malić, Silvana
engleski
A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK)
Molecular modeling and phosphorylation assay in vitro were employed to select a novel unsaturated 1, 3-dihydroxyisobutenyl thymine derivative 6 as ligand for HSV-1 TK which may be of interest as lead for the development of an positron emission tomography (PET) imaging agent. Compound 6 was successfully prepared using modified approaches. A significant improvement over the syntheses involving pathways A and B (1% and 3% overall yield, respectively), was observed using synthetic route C (14% overall yield).
6-(1, 3-Dihydroxyisobutenyl)thymine ; herpes simplex virus type 1 thymidine kinase (HSV-1 TX) ; molecular docking ; positron emission tomography (PET)
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Podaci o izdanju
21 (20)
2011.
6161-6165
objavljeno
0960-894X
1464-3405
10.1016/j.bmcl.2011.07.115