Correlation of morphological FAB classification and immunophenotyping value in recognition of morphological, cytochemical and immunological characteristics of mixed leukaemias (CROSBI ID 177568)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Boban, Dubravka ; Sučić, Mirna ; Marković- Glamočak, Mirjana ; Užarević, Branka ; Batinić, Drago ; Marušić, Matko ; Nemet, Damir ; Labar, Boris ; Hitrec, Vlasta
engleski
Correlation of morphological FAB classification and immunophenotyping value in recognition of morphological, cytochemical and immunological characteristics of mixed leukaemias
Correlation between the FAB classification and immunophenotype was studied in 169 consecutive adult patients with acute leukaemia (AL). The lineage of leukaemic cells could be determined in the majority of cases, whereas 3 patients (1.8%) remained unclassified. In 22 out of 71 patients (31%) with acute myeloid leukaemia (AML) FAB M1 and M2 types, and in 5 out of 16 patients (31%) with chronic myeloid leukaemia (CML) in myeloid blast crisis, leukaemic cells did not express myeloid lineage- related markers, indicating asynchronous expression of cell markers in a substantial proportion of patients. Flow cytometric two-colour immunofluorescence revealed mixed AL immunophenotype in 6 out of 169 patients (3.4%). This group included five CD2+AML (5% of AML tested) and one undifferentiated AL expressing CD10(CALLA), CDw65(VIM-2). The former group included FAB M1, M2, M3 and M4 forms of AML with a single cell population, and an AML M2 patient with both cytochemically and immunologically two separate populations of leukaemic cells. This further illustrates the heterogeneity of the target cell(s) for leukaemogenesis and the level of differentiation of AML cells. However, there was no difference in the treatment response and the remission duration between AML patients and patients with mixed phenotype AML.
acute leukemia cytomorphology ; immunophenotyping
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Podaci o izdanju
8
1993.
1167-1172
objavljeno
0959-8049
1879-0852
10.1016/S0959-8049(05)80309-0
Povezanost rada
Farmacija, Kliničke medicinske znanosti