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Distribution and morphology of different GABAergic interneuron subpopulations in the human neocortex (CROSBI ID 580130)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Džaja, Domagoj ; Jovanov Milošević, Nataša ; Petanjek, Zdravko Distribution and morphology of different GABAergic interneuron subpopulations in the human neocortex // SINAPSA Neuroscience Conference ’11, Central European FENS Featured Regional Meeting, Ljubljana, Slovenia, September 22-25.09.2011. SINAPSA Abstract Book, pg. 91.. 2011

Podaci o odgovornosti

Džaja, Domagoj ; Jovanov Milošević, Nataša ; Petanjek, Zdravko

engleski

Distribution and morphology of different GABAergic interneuron subpopulations in the human neocortex

Gamma-aminobutyric-acidergic (GABAergic) cells form a very heterogeneous population of neurons that play a crucial role in the coordination and integration of cortical functions. Dysfunction or cell death of several specific types has been described as a hallmark of various psychiatric and neurological disorders and it is suggested that organization of GABAergic network shows several features specific for primate neocortex. However, present data are limited and inconsistent, so our aim was to describe, in the human neocortex, distribution and morphology of cortical cells that stain for three main chemical subclasses of GABAergic neurons. Sections of human prefrontal cortex were immunochytochemically stained for parvalbumin (PV), calretinin (CR) and calbindin (CB). PV stained cells have highest density and were diffusely distributed through all cortical layers, frequently with extensive staining of processes. Sublayers of cells with heavy stained cell body were found in supragranular layers and large heavy stained cells were located in the deep part of layer VI. Vast majority of CR positive cells have heavy stained cell body and most of them were located in supragranular layers, only very sporadically in infragranular. Strongly labeled CB positive cells have formed a densely packed belt in the upper part of layer II and in the other layers, both supragranular and infragranular, they were diffusely distributed at lower density. Comparing our data with description in rodents and nonhuman primates, we concluded that organization of cortical GABA-ergic network changed highly through evolution and that even some subtle differences could be seen comparing human and rhesus monkey.

interneurons; tangential migration; ganglionic eminence; upper subventricular zone; principal glutamatergic neurons; schizophrenia

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

2011.

objavljeno

Podaci o matičnoj publikaciji

SINAPSA Neuroscience Conference ’11, Central European FENS Featured Regional Meeting, Ljubljana, Slovenia, September 22-25.09.2011. SINAPSA Abstract Book, pg. 91.

Podaci o skupu

SINAPSA Neuroscience Conference ’11, Central European FENS Featured Regional Meeting

poster

22.09.2011-25.09.2011

Ljubljana, Slovenija

Povezanost rada

Temeljne medicinske znanosti