engleski

Cyclooxygenase-2 in Dukes B colon cancer

Aims were to demonstrate immunohistochemical expression of COX-2 protein in Dukes B colon cancer and to establish a correlation with clinicopathological parameters such as: age, gender, gradus, presence of vascular invasion and patient's overall survival. We performed immunohistochemical analysis of formalin-fixed, paraffin embedded specimens form 152 Dukes B colon carcinomas, using the COX-2 monoclonal antibody. Immunohistochemical results were scored semi-quantitatively. Carcinomas were graded as low or high grade. Survival time was analyzed by Kaplan-Meier method, and the log-rank test was used to assess the differences between groups. For multivariate analysis, Cox proportional hazard regression model was used to examine several parameters simultaneously. Univariate analysis showed that positive staining for COX-2, high histological grade ; vascular invasion ; male gender and age over 60 years, were connected with shorter survival of patients with Dukes B colon cancer (0.023< p<0.001). However, multivariate analysis have shown that the high COX-2 expression in Duke's B colon cancer was unrelated to overall patient survival (RR=1.4 ; p=0.311). Expression of COX-2 in tumor epithelial cells does not seem to be related to survival in patients with colon cancer Dukes B.

COX-2; colon cancer

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