Genetic association studies in thrombophilia research (CROSBI ID 580333)
Prilog sa skupa u časopisu | izvorni znanstveni rad
Podaci o odgovornosti
Šimundić, Ana-Maria
engleski
Genetic association studies in thrombophilia research
Genetic association studies explore the association between genetic polymorphisms and a certain trait, disease or predisposition to disease. It has long been acknowledged that many genetic association studies fail to replicate their initial positive findings. This raises concern about the methodological quality of these reports. Case-control genetic association studies often suffer from various methodological flaws in study design and data analysis, and are often reported poorly. Flawed methodology and poor reporting leads to distorted results and incorrect conclusions. Many journals have adopted guidelines for reporting genetic association studies. In this review, some major methodological determinants of genetic association studies will be discussed.
thrombophilia; genetic association; methodology
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Podaci o prilogu
S115-S118.
2010.
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objavljeno
Podaci o matičnoj publikaciji
Clinical chemistry and laboratory medicine
Šimundić, Ana-Maria ; Muszbek, László ; Topić, Elizabeta ; Horvath, Andrea Rita
Berlin: Walter de Gruyter
1434-6621
Podaci o skupu
New Trends in Classification, Diagnosis and Management of Thrombophilia
pozvano predavanje
23.10.2010-24.10.2010
Dubrovnik, Hrvatska