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Is there a role for TNFα antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique (CROSBI ID 177884)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Distler, J.H.W ; ... ; Martinović, Dušanka ; ... ; Radić, Mislav ; Rendić, S. ; ... ; Matucci-Cerinić, M. ; ... ; Distler, O. Is there a role for TNFα antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique // Clinical and experimental rheumatology, 29 (2011), S65; S40-S45

Podaci o odgovornosti

Distler, J.H.W ; ... ; Martinović, Dušanka ; ... ; Radić, Mislav ; Rendić, S. ; ... ; Matucci-Cerinić, M. ; ... ; Distler, O.

engleski

Is there a role for TNFα antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique

Objectives were To obtain experiences and expert opinion on treatment of SSc patients with TNF-α antagonists. An investigation was carried out among the EUSTAR centres into their expertise on use of TNF-α antagonists. Assessment forms on the frequency of TNF-α inhibitor use were distributed to EULAR Scleroderma Trials and Research Group (EUSTAR) centres. Afterwards, a three round Delphi exercise was performed to obtain expert consensus on the use of TNF-α inhibitors in SSc. Seventy-nine centres returned information on use of TNF-α antagonists in SSc patients. A total of 65 patients were treated with TNF-α inhibitors in 14 different centres. Forty-eight of the 65 patients treated with TNF-α inhibitors improved. Improvement was mainly seen in patients with arthritis, whereas the effects on fibrosis varied. In the first round of the subsequent Delphi approach, 71 out of 79 experts stated that they would use TNF-α antagonists in SSc. Arthritis was suggested as an indication for TNF-α antagonists by 75% of the experts. However, after the third stage of the Delphi exercise, the acceptance for the off-label use of TNF-α antagonists decreased and 59% recommended that TNF-α antagonists should not be used or only used in clinical trials in SSc patients, while 38% of the experts suggested the use of TNF-α antagonists for arthritis associated with SSc. Most of the experts do not recommend the routine use of TNF-α antagonists in systemic sclerosis. Arthritis might be a potential indication in SSc, although controlled clinical trials with TNF-α antagonists are needed before general recommendations can be given.

TNFα antagonists; systemic sclerosis

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Podaci o izdanju

29 (S65)

2011.

S40-S45

objavljeno

0392-856X

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost