Conserved signal sequences specific for processing of innate immunity antimicrobial peptides (CROSBI ID 580567)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Petrov, Dražen ; Juretić, Davor
engleski
Conserved signal sequences specific for processing of innate immunity antimicrobial peptides
Antimicrobial peptides (AMPs) are molecules involved in the defense mechanisms of a wide range of organisms. It has been shown for few families of host defense peptides that different C-terminal AMPs are derived from a single family of precursor polypeptides with unique features and remarkably well conserved sequence both within and between species. We showed that, for a large set of host defense peptide sequences taken from the antimicrobial database AMPB2, the signal peptide and acidic propeptide sequences of host defense peptides are highly conserved and specific for host defense peptides. We pointed out that processing of immature host defense peptides deserves further study since it may lead to discovery of highly conserved subset of signal recognition particles and peptidases specific for such peptides. Furthermore, we used this property of signal peptides to find new mature peptides (AMPs) by searching EST using signal peptide sequence as a query for the TBLASTP. In addition, we used cluster analysis for identification of signal peptide families.
antimicrobial peptides; signal sequences; conserved
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Podaci o prilogu
47-47.
2010.
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objavljeno
978-953-7155-15-5
Podaci o matičnoj publikaciji
Book of Abstracts AMP2010
Juretić, Davor ; Separovic, Frances
Split: Sveučilište u Splitu ; Prirodoslovno-matematički fakultet Sveučilišta u Splitu
Podaci o skupu
AMP 2010 Australia-Croatia Workshop on Antimicrobial Peptides and Summer School in Biophysics PhD Programme
poster
09.08.2010-14.08.2010
Split, Hrvatska