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Conserved signal sequences specific for processing of innate immunity antimicrobial peptides (CROSBI ID 580567)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Petrov, Dražen ; Juretić, Davor Conserved signal sequences specific for processing of innate immunity antimicrobial peptides // Book of Abstracts AMP2010 / Juretić, Davor ; Separovic, Frances (ur.). Split: Sveučilište u Splitu ; Prirodoslovno-matematički fakultet Sveučilišta u Splitu, 2010. str. 47-47

Podaci o odgovornosti

Petrov, Dražen ; Juretić, Davor

engleski

Conserved signal sequences specific for processing of innate immunity antimicrobial peptides

Antimicrobial peptides (AMPs) are molecules involved in the defense mechanisms of a wide range of organisms. It has been shown for few families of host defense peptides that different C-terminal AMPs are derived from a single family of precursor polypeptides with unique features and remarkably well conserved sequence both within and between species. We showed that, for a large set of host defense peptide sequences taken from the antimicrobial database AMPB2, the signal peptide and acidic propeptide sequences of host defense peptides are highly conserved and specific for host defense peptides. We pointed out that processing of immature host defense peptides deserves further study since it may lead to discovery of highly conserved subset of signal recognition particles and peptidases specific for such peptides. Furthermore, we used this property of signal peptides to find new mature peptides (AMPs) by searching EST using signal peptide sequence as a query for the TBLASTP. In addition, we used cluster analysis for identification of signal peptide families.

antimicrobial peptides; signal sequences; conserved

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Podaci o prilogu

47-47.

2010.

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objavljeno

978-953-7155-15-5

Podaci o matičnoj publikaciji

Book of Abstracts AMP2010

Juretić, Davor ; Separovic, Frances

Split: Sveučilište u Splitu ; Prirodoslovno-matematički fakultet Sveučilišta u Splitu

Podaci o skupu

AMP 2010 Australia-Croatia Workshop on Antimicrobial Peptides and Summer School in Biophysics PhD Programme

poster

09.08.2010-14.08.2010

Split, Hrvatska

Povezanost rada

Fizika, Biologija