Ganglia/Nerve Fibers Ratio Correlates with the Need for Surgery in Patients Diagnosed with Hirschsprung's Disease Allied Disorder (HAD) (CROSBI ID 178615)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Gašparović, Ivan ; Kovač, Dražen ; Peršić, Mladen ; Slavić, Irena ; Nikolić, Hari ; Jonjić, Nives
engleski
Ganglia/Nerve Fibers Ratio Correlates with the Need for Surgery in Patients Diagnosed with Hirschsprung's Disease Allied Disorder (HAD)
Treatment in Hirschsprung's disease allied disorder (HAD) is surgical. In HAD, surgery is always a question. We investigated the value of ganglia/nerve fibers ratio in prediction of the need for invasive procedures in HAD. Sections of full thickness bowel specimens of 14 patients were stained with antibodies marking ganglia (Anti-Neuron-Specific Enolase, Anti-NSE) and marking nerve fibers (S-100). Six out of seven patients indicated for surgery had low ganglia/nerve fibers ratio. Five out of seven patients, not showing the need for surgery, had high ganglia/nerve fibers ratio. We propose that a lower ganglia/nerve fiber ratio can be used as a predictor of increased need for surgery in HAD.
Hirschsprung's disease Allied Disorder (HAD); Ganglia/Nerve Fibers Ratio
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Podaci o izdanju
30 (6)
2011.
405-413
objavljeno
1551-3815
10.3109/15513815.2011.618871
Povezanost rada
Kliničke medicinske znanosti