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Pregled bibliografske jedinice broj: 551869

Zbornik radova

Autori: Boban, Marina; Šarac, Helena; Mladinov, Mihovil; Süßmair, Christine; Ackl, Nibal; Bader, Benedikt; Danek, Adrian; Mimica, Ninoslav; Hof, Patrick R; Šimić, Goran
Naslov: CSF total tau and tau protein phosphorylated at threonine 181 in the differential diagnosis of Alzheimer's disease and vascular cognitive impairment
Izvornik: European Journal of Neurology 18 (Suppl. 2) - Abstracts of the 15th congress of the European Federation of Neurological Societies
ISSN: 1351-5101
Skup: 15th congress of the European Federation of Neurological Societies
Mjesto i datum: Budimpešta, Mađarska, 09-13.09.2011.
Ključne riječi: Cerebrospinal fluid; dementia; Alzheimer's disease; vascular cognitive impairment
Sažetak:
Alzheimer's disease (AD) and vascular cognitive impairment (VCI) are the two most common causes of dementia in older age groups. Due to inadequacy of current clinical diagnostic criteria in differential diagnosis of dementia, the identification of new biomarkers that would help establishing the diagnosis and primary cause of the dementia is therefore of great relevance. The aim of this study was to investigate the diagnostic accuracy of two potential CSF biomarkers, total tau protein (t-tau) and tau protein phosphorylated at threonine 181 (p-tau181) in the differential diagnosis of patients with AD and VCI. The concentrations of CSF biomarkers were measured in 29 AD patients, 12 VCI patients and 25 control subjects. The CSF concentrations of both markers were significantly higher in AD group compared to VCI (p>0.001) group and control subjects (p<0.001) ; however none fulfilled the criteria for the "ideal" marker (sensitivity and specificity higher than 85%). Finally, using logistic regression analysis with t-tau and p-tau181 as independent variables led to improvement in diagnostic accuracy with correct classification in more than 85% of cases.
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Web of Science: Science Citation Index Expanded
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Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1080003-0019, 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Upisao u CROSBI: relja@mef.hr (relja@mef.hr), 23. Stu. 2011. u 09:12 sati



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