Clinical and neurophysiological changes in patients with pineal region expansions (CROSBI ID 581640)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Hajnšek, Sanja ; Paladino, Josip ; Petelin, Željka ; Nanković, Sibila ; Mrak, Goran ; Lupret, Velimir
engleski
Clinical and neurophysiological changes in patients with pineal region expansions
Aim of the study: In the last 20 years neurological and neurosurgical follow up of our patients with pineal region expansions (118 patients) pointed to certain clinical and neurophysiological regularities. We decided to perform retrospective study which included 84 patients in the period from 1992 to 2010. Methods: The study included 55 women and 29 men, mean age 30.08± 13.93 years, with positive brain MRI - 70 patients (83.4%) had simple pineal gland cysts, and 14 patients (16.67%) had expansive process in pineal region with compressive effect. Operation with supracerebellar infratentorial approach was performed in 70 patients. Pathohistological analysis revealed pineocytomas in 11 cases, pinealoblastomas in 2 cases, one case of teratoma, while other patients had pineal gland cysts. Results: All patients had “dysrrhytmic headache“, while 32 patients (38%) had epileptic phenomena - primary generalized seizures. Patients had common EEG pattern with paroxysmal discharges of 3 Hz (or more than 3 Hz) spike-and-wave complexes. Conclusions: This study points to often appearance of seizures that clinically and neurophysiologically present as primary generalized epilepsy in patients with pineal region expansions. Our hypotheses are that mass effect on the surrounding veins that affects normal perfusion, hemosiderin deposists, compressive effect on the quadrigeminal plate and the aqueduct of the midbrain, as well as secretion disturbances of anticonvulsive agent melatonin can be involved in the pathogenesis of seizures. We suggest to perform high resolution brain MRI with special demonstration of pineal region in all young patients that have seizures and specific EEG changes.
pineal expansions; neurophysiology; clinical changes
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Podaci o prilogu
45-45.
2011.
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objavljeno
Podaci o matičnoj publikaciji
Acta clinica Croatica
Rotim, Krešimir ; Ledić, Darko
Zagreb: Klinički bolnički centar Zagreb (KBC Zagreb)
0353-9466
Podaci o skupu
6th Congress Of The Croatian Neurosurgical Society and the Joint Meeting with The Slovenian Neurosurgical Society
pozvano predavanje
25.05.2011-28.05.2011
Opatija, Hrvatska
Povezanost rada
Kliničke medicinske znanosti