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Clinical and neurophysiological changes in patients with pineal region expansions (CROSBI ID 581640)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Hajnšek, Sanja ; Paladino, Josip ; Petelin, Željka ; Nanković, Sibila ; Mrak, Goran ; Lupret, Velimir Clinical and neurophysiological changes in patients with pineal region expansions // Acta clinica Croatica / Rotim, Krešimir ; Ledić, Darko (ur.). 2011. str. 45-45

Podaci o odgovornosti

Hajnšek, Sanja ; Paladino, Josip ; Petelin, Željka ; Nanković, Sibila ; Mrak, Goran ; Lupret, Velimir

engleski

Clinical and neurophysiological changes in patients with pineal region expansions

Aim of the study: In the last 20 years neurological and neurosurgical follow up of our patients with pineal region expansions (118 patients) pointed to certain clinical and neurophysiological regularities. We decided to perform retrospective study which included 84 patients in the period from 1992 to 2010. Methods: The study included 55 women and 29 men, mean age 30.08± 13.93 years, with positive brain MRI - 70 patients (83.4%) had simple pineal gland cysts, and 14 patients (16.67%) had expansive process in pineal region with compressive effect. Operation with supracerebellar infratentorial approach was performed in 70 patients. Pathohistological analysis revealed pineocytomas in 11 cases, pinealoblastomas in 2 cases, one case of teratoma, while other patients had pineal gland cysts. Results: All patients had “dysrrhytmic headache“, while 32 patients (38%) had epileptic phenomena - primary generalized seizures. Patients had common EEG pattern with paroxysmal discharges of 3 Hz (or more than 3 Hz) spike-and-wave complexes. Conclusions: This study points to often appearance of seizures that clinically and neurophysiologically present as primary generalized epilepsy in patients with pineal region expansions. Our hypotheses are that mass effect on the surrounding veins that affects normal perfusion, hemosiderin deposists, compressive effect on the quadrigeminal plate and the aqueduct of the midbrain, as well as secretion disturbances of anticonvulsive agent melatonin can be involved in the pathogenesis of seizures. We suggest to perform high resolution brain MRI with special demonstration of pineal region in all young patients that have seizures and specific EEG changes.

pineal expansions; neurophysiology; clinical changes

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Podaci o prilogu

45-45.

2011.

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objavljeno

Podaci o matičnoj publikaciji

Acta clinica Croatica

Rotim, Krešimir ; Ledić, Darko

Zagreb: Klinički bolnički centar Zagreb (KBC Zagreb)

0353-9466

Podaci o skupu

6th Congress Of The Croatian Neurosurgical Society and the Joint Meeting with The Slovenian Neurosurgical Society

pozvano predavanje

25.05.2011-28.05.2011

Opatija, Hrvatska

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost