engleski

Chromosome abnormalities of small round cell tumors

During last twenty years considerable progress has been achieved in the field of cytogenetics of malignant diseases. Specific clonal cheomosomal abnormalities have been of practical value for the precise diagnosis and determination of prognosis. Investigation carried out so far have mostly dealt with hemoblastosis, whereas studies in children with solid tumors and lymphomas are rare. Small round (SRCT) is a heterogenous group of disease that include Ewing sarcoma, neuroblastoma, rhabdomyosarcoma and non-Hodgkin lymphoma. Due to similar histology this group of diseases is the most serious diagnostic probleme. The precise diagnosis is of particular importance since for different type of disease differing therapy is needed. In this study we present the results of cytogenetic analysis in 30 children with SCCT. The aim of this investigation is to determine the frequency and type of chromosome abnormalities, and evaluate the feasibility of cytogenetic analysis in differential diagnosis and prognosis. Cytogenetic analysis revealed clonal chromosomal abnormalities in 70% of children. The analysis revealed nonrandom involvement of chromosomal types in numerical and structural aberrations. This investigation confirms the diagnostic importance of cytogenetic investigations in SRCT of children.

Cytogenetics; Children; Solid tumors

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