THE INFLUNCE OF POSTOPERATIVE PAIN MANAGEMENT TECHNIQUES ON THE INNATE IMMUNITY IN PATIENTS WITH COLORECTAL CANCER (CROSBI ID 582103)
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Podaci o odgovornosti
Mrakovčić-Šutić, Ines ; Golubović, Vesna ; Golubović, Snježana ; Sotošek Tokmadžić, Vlatka ; Petković, Marija
engleski
THE INFLUNCE OF POSTOPERATIVE PAIN MANAGEMENT TECHNIQUES ON THE INNATE IMMUNITY IN PATIENTS WITH COLORECTAL CANCER
During the postoperative recovery, accompanied with neuroendocrine, metabolic and immune alteration, chronic pain as a results of physical insults, inflammation, cancer, visceral pathologies and nerve damage represents one of the most important difficulties that confront surgical patients. Postoperative pain contributs to immunosupression as a result of interaction between central nervous and immune systems. The postoperatively activated hypotalamo-pituitary-adrenocortical and sympatoadrenal axis are important modulators of immune response. Cancer patients represent one of the most sensitive patients for analgesia and surgical stress with accompanied alteration of innate and aquired immune response. The aim of this study was to compare two postoperative pain management techniques in patients undergoing colorectal cancer surgery on expression of cytolitic molecule perforin in peripheral blood mononuclear cells, as well as to analyze the relationship between the number of Treg and NKT cells and clinical outcomes of these patients. Methods: Phenotype of lymphocytes and perforin expression were analyzed using intracellular and surface immunofluoresecncy and flow cytometric analysis (FACSCalibur). Results: 20-30% of PBL in all examine group are perforin positive (total perforin is significantly higher in patients underwent epidural analgesia than in intravenous experimental group). Conclusions: human perforin is differentially expressed in distinct sub-populations of peripheral blood lymphocytes of patients with colorectal cancer, implicating the important role of postoperative pain management techniques on expression of perforin positive cells and their role in naïve immune response and cytotoxic activity of peripheral blood lymphocytes. The appropriate postoperative pain management can modulate immune response of these patients after colorectal surgery.
colorectal cancer; epidural analgesia; intravenous analgesia; perforin
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Podaci o prilogu
2010.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
Godišnja skupština Hrvatskog imunološkog društva 2010 s međunarodnim sudjelovanjem
predavanje
07.10.2010-10.10.2010
Mali Lošinj, Hrvatska