engleski

Cross-talk between regulatory T cells (Tregs) and NKT cells in modulation of innate immunity folowing burn injuries

Imbalanced innate immunity can be a springboard for the development of various pathological conditions: tumor, autoimmune diseases, hypersensitivity, slower, hindered or incomplete healing, or lethal outcome during other illnesses. Regulatory T cells (Tregs) and NKT cells, as carries of innate immunity play a key role in the control of pathological immune responses. The most specific marker that distinguishes regulatory from conventional T cells is forkhead box transcription factor (Foxp 3). Predominant cell types that expressed Foxp 3 are CD4+CD25+ and characteristic of subpopulations which are Foxp 3 negative are their regulatory function lacked. Natural Tregs have the possibility to suppress multiple cell types involved in immunity and inflammation by inhibition the proliferation, immunoglobulin production, the blocking of NK and NKT-cell cytotoxicity, as well as, the function and maturation of dendritic cells. It seems that the efficacy of Treg-based therapy depends on the antigen specificity of these regulatory T cells The aim of the study: Our hypothesis about regulatory network of Treg and NKT cells, were studied on the severe change of natural immunity: on burns as example of local and systemic injuries. Results: Functional changes in regulatory T and NKT cells correlate with clinical stages, prognosis of illnesses and success of treatment of burned patients. Trges and NKT cells were significantly decreased in patients with burn injuries and is comparable with the level of the disorders. Conclusion: Tregs and NKT monitoring may contribute to better treatment of patients suffering from burn injuries and pain, contributing to faster recovery and/or reducing infections in all conditions characterized by impaired organism resistance.

burns; NKT cells; Tregs

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