Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease (CROSBI ID 179904)
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Podaci o odgovornosti
Palada, Vinko ; Terzić, Janoš ; Mazzulli, Joseph ; Bwala, Grace ; Hagenah, Johann ; Peterlin, Borut ; Hung, Albert Y. ; Klein, Christine ; Krainc, Dimitri.
engleski
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease
Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ(2) = 11.65 ; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.
Parkinson's disease; Parkinsonism; Histamine; HNMT; Association studies in genetics
Genetic Reports Abstracts
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Podaci o izdanju
33 (4)
2012.
836e1-836e3
objavljeno
0197-4580
10.1016/j.neurobiolaging.2011.06.015
Povezanost rada
Temeljne medicinske znanosti