engleski

Endothelial lipase plasma levels are increased in patients with significant carotid artery stenosis and history of neurological impairment

Background: Endothelial lipase (EL) is a phospholipase expressed predominantly by vascular endothelial cells. The goal of the present study was to examine whether EL plasma levels in patients with carotid artery stenosis differ between those with previous history of neurological impairment and those without neurological symptoms. Methods: EL plasma levels were measured by a competitive ELISA assay. Results: EL plasma levels were significantly higher in the symptomatic, compared with the asymptomatic group (mean 489.61 ± 145 ng/ml (n = 31) vs. 388.39 ± 133 ng/ml (n = 24), t-test, P = 0.011). Conclusions: We concluded that increased EL plasma levels reflect the patients’ overall susceptibility for cerebrovascular events.

Atherosclerosis; Carotid artery stenosis; Endothelial lipase; Neurological impairment; Carotid endarterectomy

Rad je izrađena u okviru Znanstvenog projekta Republike Austrije (Austrian Science Foundation (FWF ; grant P19473-B05) 2005-2010) i Međunarodne suradnje Medicinskog fakulteta Sveučilišta u Zagrebu i Medicinskog Univerziteta u Grazu (Agreement on Co-operation between the University of Zagreb School of Medicine and Medical University of Graz concluded on February 21 2005. Project title: Expression of endothelial lipase and inflammatory molecules in human carotid atheroscelrotic plaques. Principal investigators: Professor Saša Frank (Graz) and Assistant Professor Vesna Degoricija (Zagreb) Duration: 2005-2010).