engleski

Environmentally-friendly organic chemistry without bulk organic solvent: mechanochemical synthesis of thioureas

In the search for a preparative method that would meet the requirements of green chemistry, a mechanical treatment of (in)organic reagents by simply grinding them together has reappeared as one of the solutions to pollution related issues of the modern chemical industry. Recent advancements in the solid-state synthetic methodology, such as liquid-assisted grinding (LAG), allow a simple, rapid and clean synthesis of a variety of materials, including cocrystals, salts or coordination polymers. In addition, powder X-ray diffraction (PXRD) often enables the structure determination to be carried out without using bulk solvents and the need to grow single crystals. Bearing this in mind, we now extend the previously proposed „solvent-free research“ paradigm from metal-organic chemistry to the field of organic synthesis as a part of our continuing efforts in developing new methods of laboratory work. In this presentation, we report on the quantitative synthesis of structurally diverse thiourea derivatives by automatised ball-milling of the starting material. On a selection of mechanochemically prepared compounds, we have utilised PXRD for structure determination, thus implementing the „solvent-free research“ paradigm into an organic chemistry laboratory.

solvent-free synthesis; mechanochemistry; green chemistry

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