engleski

The generation and in vivo differentiation of murine embryonal stem cells genetically null for either N- cadherin or N-and P-cadherin

Tumors lacking either N-cadherin or N- and P- cadherin cintained more stiated muscle (apparently cardiac muscle) than heterozygot controls, and this was most strinkingly conspicuous in teratomas from N-and P-cadherin null cells. This more pronounced differentiation was not seen for all tissues, however, as structures with a simple neural tube- like morphology were never found in teratomas lacking both N-and P-cadherin and organoid- like were rare in Ncad-/-tissue.

teratoma; cadherin; ES cells

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