engleski

Positive reproductive family history for spontaneous abortion : predictor for recurrent miscarriage in young couples

The etiology of recurrent spontaneous abortions (RSA) (in chromosomally normal parents) is still unexplained. Currently, it is still unclear whether or not some factors (like spontaneous abortions, SA) which occur among extended family members can create a predisposition that may end with a terminated pregnancy. Therefore, this study comprises two parts: a) the epidemiological part, to evaluate the relationship between RSA in 567 couples and the frequency of SA among their first (I), second II) and third (III) generation relatives, and b) the genetic part, presenting whether parental and fetal chromosomal status may predispose the occurrence of RSA. Study design Couples (567) having one or more SA were analyzed in this retrospective case-control study. The family reproductive history data was collected from their medical charts. Results The total number of SA found in 567 couples was 1174. The largest number of abortions occurred between the 8th and 10th week of gestation. The majority of spouses had normal karyotypes (88.5% and 91%). Out of the remaining spouses, 65% (females) and 76% (males) expressed constitutional chromosomal variation, mostly the pericentric inversion of chromosome 9. Cytogenetic analysis performed on aborted material samples showed some type of change in 40% of cases. The family reproductive history data indicated that the number of SA among the couples’ I, II and III generation relatives happened with a frequency of two to three times higher than that of the general population (55.5, 47.6 and 32.6% for female relatives, and 45.8, 44.1 and 15.1% for male I, II and III generation relatives). Conclusion Positive reproductive family history for SA might be the causal factor for RSA and can also predetermine women that are of greater susceptibility to preterm pregnancy.

recurrent spontaneous abortion ; family history

nije evidentirano